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Dexfen-Phen - The combination of Redux or Dexfenfluramine - a more refined compound that, like Fen-Phen, affects seratonin levels, but with fewer side effects than Fenfluramine - and Didrex also became a sensation. Unfortunately, neither combination was tested for safety... By the summer of 1997, the Food and Drug Administration (FDA) found 24 cases of heart-valve deterioration in women who had taken the Fen-Phen combination. Throughout the summer, the FDA received additional reports of heart disease, including reports from patients who had taken only Fenfluramine or Dexfenfluramine. In September 1997, The FDA requested drug manufacturers to voluntarily withdraw Fenfluramine and Dexfenfluramine. The FDA also recommended that patients using either Fenfluramine or Dexfenfluramine stop doing so. To read the FDA statement regarding the withdrawals, please click here.The FDA did NOT, however, request the withdrawal of the third drug involved in the cocktails, Didrex. 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